Cardiopulmonary bypass (CPB) is a common practice in cardiac surgery. In this technique, venous blood is directed from the venous system to a heart-lung machine and then returned to the aorta through an inserted arterial cannula. Among the perioperative and postoperative complications, a reduction of cerebral perfusion, resulting in neurological complications, is observed, linked to the reduction of blood flow from the aortic arch to the carotid artery. Related to the altered flow conditions induced by the arterial cannula, a second major complication is an increased risk of thromboembolic events, caused by the mechanical activation of platelet aggregation pathways, induced by the highly disturbed flow patterns.

Thus, the study of the effect of cannulation and its influence on the described mechanisms is of high clinical relevance and could allow the optimization of therapeutic performances. Currently, there is very little guidance for the surgeons regarding optimal clinical use parameters.